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The hair loss market is huge and sometimes baffling, with a host of products with varying efficacy (or lack of it) and side effects.
One of the leading products in hair renewal is dutasteride, available as both oral and topical solutions. Dutasteride reduces hair loss from the scalp and prevents the body from converting testosterone into dihydrotestosterone (DHT, which causes hair loss). In fact, as discovered in a 2004 clinical trial, dutasteride blocks over 98% of DHT production.
However, oral dutasteride comes with side effects. These can include erectile dysfunction (ED), premature ejaculation (PE), and reduced sex drive. Let’s be honest… there’s little consolation in having a full head of hair if you find yourself unable to perform in the bedroom.
But there’s good news – XYON has developed a topical treatment of dutasteride that goes above and beyond typical treatments in reducing or eliminating many of the side effects of the oral version. Let’s look a little more closely at this remarkable treatment, so you can decide whether it might be right for you.
XYON Topical DutasteridePros + Cons
Pros
- Lower side effect risk: 92% less systemic absorption with topical application, rather than oral, dutasteride ensures fewer side effects (usually sexual).
- More effective: XYON’s gel technology combined with SiloxysSystem™ Gel allows for up to 2% Dutasteride solution and drives the formula precisely into the scalp.
- Compounded just for you: XYON offers a personalized formula with your medical history, lifestyle, age, and other factors in mind.
- Lasts 10-17x longer: The controlled release mechanism gradually deposits active ingredients into your follicle sites over multiple hours rather than all at once.
- Easy to apply: Many customers prefer it to the aerosol sprays and liquid droppers common to other topical treatments.
Cons
- Not FDA-approved: Dutasteride for hair loss is currently sold off-label, which simply means it was approved to treat another condition than hair loss initially.
- Only 1 active ingredient: Combining minoxidil or finasteride with dutasteride could potentially yield even better results.
- Not cheap: Works out as more expensive than most topical creams and gels.
Best Topical Dutasteride Online
There are a lot of factors to take into account when choosing a hair loss treatment. Even when considering only topical products, there are several impactful options.
Xyon vs Strut vs Happy Head - Which Dustasteride is Best? | |||
|---|---|---|---|
| Dutasteride product | Topical Dutasteride | Topical Dutasteride | Topical Dutasteride + Minoxidil |
| Dutasteride price | $129/mo (billed $387 quarterly) | $69/mo | $44 for first month $89/mo thereafter |
| Form (spray/gel/drops?) | Gel | Cream | Liquid dropper |
| Dutasteride concentration | ≤ 2% | ≤ 0.1% | ≤ 0.3% |
| Other active ingredients | SiloxysSystem™ Gel | 0.1% Dutasteride ≤ 7.5% Minoxidil ≤ 0.0125% Tretinoin ≤ 0.01% Fluocinolone | 0.3% Dutasteride ≤ 8% Minoxidil ≤ 0.001% Retinoic Acid ≤ 1% Hydrocortisone. |
| Controlled release of dutasteride on scalp? | ✅ SiloxysSystem™ for slow release. | ❌ | ❌ |
| Quantity | 3 month supply | 1 month supply | 1 month supply |
| Free online consultation? | ✅ | ✅ | ✅ |
| Other hair loss treatments? | Topical Finasteride Oral Finasteride | Topical Finasteride Oral: Dutasteride and finasteride | Topical: Finasteride, minoxidil, dutasteride, and spironolactone Oral: Finasteride, minoxidil, dutasteride, and spironolactone |
| Website |
Strut Health vs. Happy Head
As “topical” suggests, this is a gel hair loss solution rather than a pill or oral product. XYON’s dutasteride is even more unique because it’s a gel that uses a trademarked delivery technology called SiloxysSystem™. The active ingredient (dutasteride) is encased in time-release gel nanoparticles, which target the sites of follicle growth. This means that more of the dutasteride gets to exactly where needed.
This delivery method also means that less of the dutasteride enters the bloodstream, increasing efficacy where it’s beneficial and decreasing side effects.
Related reading:
- XYON Shampoo + Conditioner Review
- XYON Topical Finasteride Review
- Best Topical Dutasteride – Where to Get Dutasteride Online
Dutasteride vs Finasteride: What's better for hair loss?
Dutasteride and finasteride are considered the gold standard for treating hair loss. But what makes them different? Can you use both, or should you just choose one, and if so, which is better for your scalp: finasteride or dutasteride?
Both compounds are designed to address men’s hair loss. Male pattern baldness, known scientifically as androgenetic alopecia, is caused by an enzyme (5-alpha reductase) that converts testosterone into DHT, causing hair follicle shrinkage.
This type of baldness makes it hard to sustain long, thick, and pigmented hair growth over time. By inhibiting the 5-alpha reductase enzyme’s action, finasteride and dutasteride can halt and even reverse some of this process.
The difference? Which 5-alpha reductase enzymes are targeted – Type 1 or Type 2. Finasteride targets only the Type 2 isoenzyme, whereas Dutasteride works on both, resulting in an even greater DHT reduction.
What sort of difference does this make? While finasteride can cause around a 70% DHT reduction, dutasteride raises the bar to 90%+.
However, finasteride can be more effective in the earliest stages of hair loss, whereas dutasteride may prove more effective if you’re some way into your male pattern baldness.
The unfortunate part of the oral version of these meds is the severe side effect profile because they interfere with normal hormone production and affect areas of the body other than the scalp. These can include reproductive and neurological systems (the brain), like:
- Erectile Dysfunction and Dysejaculation
- A lowering of sexual libido
- Possible feminization characteristics such as enlarged breast tissue.
If in doubt, always consult a dermatologist or hair loss professional before making any decisions, which are available by getting started with XYON.
What makes XYON's Dutasteride unique?
How does XYON handle this downside of oral dutasteride? Switching to a topical formulation can greatly reduce side effects, particularly one including the SiloxySystem™ slow-release gel. Less of the active ingredient needs to be applied daily, and more of it is absorbed into follicle sites rather than the user’s bloodstream.
SiloxysSystem™ gel further improves efficacy by slowly releasing dutasteride onto your scalp rather than applying it all at once. Tests have shown that 24 hours after application, SiloxysSystem keeps 10-17 times more of the active ingredient in the user’s dermis than rival topical formulations would be.
The gel also contains liposomes, round synthetic molecules that allow the medication to reach hair follicles deep in the dermal layers, bypassing the skin’s own lipid protection. Topical creams and gels containing liposomes ensure their active ingredients penetrate fully, delivering their effect below the epidermis (upper skin layer) through to the dermis layer beneath, where follicles are rooted.
Believe it or not, XYON’s innovations go even further. Whereas many topical dutasteride preparations using liposomal gels can deliver their ingredients, they cannot easily regulate their release and absorption. XYON’s trademarked SiloxysSystem™ places a mesh-like matrix over the scalp, limiting movement and allowing a slow, gradual seepage of dutasteride into the skin.
Does XYON SiloxysSystem™ improve dutasteride's effectiveness?
Dutasteride already has a longer half-life than other prescriptions for hair loss. When combined with XYON’s slow-release technology and extended presence in the hair follicles, XYON’s gel has plenty of time to demonstrate superior outcomes in hair loss reduction and regrowth.
Dutasteride is a larger molecule than finasteride. This gives it a lower degree of scalp penetration compared to other topical treatments. XYON’s SiloxySystem™ overcomes dutasteride’s greater molecular size to boost solubility and drive the formula into the scalp.
The Verdict: Is XYON Topical Dutasteride legit for hair loss?
XYON Dutasteride Gel is ideal for men looking to…
…address significant hair loss.
Since dutasteride achieves a 90%+ DHT reduction, it’s one of the most effective products for halting and/or reversing hair loss. It won’t work miracles, but XYON’s Topical Dutasteride is a powerful hair loss treatment that may be your best chance at regaining a lush, healthy head of hair. Especially if you’ve left treating it a little late, or if your loss has been sudden or dramatic, XYON’s more expensive solution could be your answer.
…easily apply hair loss treatment.
A simple, odorless rub-on gel can be applied to your dry scalp. There’s no need for a dropper or finagling help from someone else to apply. Then, you can rely on the XYON formulation’s slow-release mechanism to ensure that the active ingredients find their way to where they are most useful – your follicles.
…minimize sexual side effects.
XYON’s slow-release mechanism and topical application minimize the absorption of dutasteride into the bloodstream while enhancing the gel’s efficacy for hair loss prevention and regrowth. Therefore, XYON dutasteride topical gel is a great product for reducing the unwanted and awkward sexual side effects that DHT-blockers can cause.
Frequently Asked Questions (FAQs)
How much does XYON Topical Dutasteride cost?
XYON topical dutasteride is available on subscription only. It costs $387 for a 3-month subscription (the minimum time it could take to see demonstrable effects), which works out to $129 a month. Discount codes and offers may be available on their site.
A virtual dermatologist consultation is included in the price.
How does XYON’s consultation work?
- Set up a membership: This ensures that your personal information remains private between you and XYON’s clinicians, asking for your name, email, DOB, and biological sex. You’re also asked if you live with someone who is pregnant or trying to get pregnant (as there could be side effects if that person came into contact with the product) and at what age you first noticed your hair loss.
- Upload photos: Share a photograph or two of your scalp and identify which pattern of hair loss you are experiencing from a set of images.
- Dermatologist review: In most cases, your XYON dermatologist can obtain the information required to determine eligibility for treatment through online consultation. You will be able to ask questions of the dermatologist through online chat, offering unparalleled convenience.
- Review treatment options: These could include XYON topical dutasteride unless your clinical information implies an alternative course of treatment.
How long does it take to notice results from XYON Topical Dutasteride with SiloxysSystem Gel?
Most users begin to see favorable results within a few months of regular application of XYON Topical Dutasteride, with continued improvement over a year or longer. For some, it may take up to six months for a noticeable change to occur. This all depends upon when your hair loss began, your age, and your genetics.
How do I use/apply XYON topical dutasteride with SiloxysSystem Gel?
The gel can simply be massaged into the scalp at the affected areas, and the canister is designed to dispense one application. Dosage and application will depend upon the user, so consult a XYON dermatologist or trichologist for concrete advice.
What other hair loss products does XYON offer?
XYON produces a similar gel product with finasteride, which also uses the SiloxySystem™ slow-release technology. In addition, they sell oral finasteride capsules for $105 for a three-month subscription.
Curious where to start?
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Methodology
We conduct extensive research to evaluate the pricing, effectiveness, accessibility, overall quality, and user experience of every telehealth service we review. This also includes examining and comparing each provider to comparable telemedicine alternatives. We also evaluate usability, treatments, prescription delivery time, and more to determine the best value for those seeking fast and reliable telehealth services.
| Review Process | Key Metrics | Weighting |
|---|---|---|
| Sign up online | – ease to complete intake form – affordability – upfront commitment or subscription required? – money back guarantee or refund policy? | 0.5 |
| Vitual consult with provider / determine eligibility | – ease to get appointment to determine eligibility – need to leave house for labs or other in-person care? | 1 |
| Shipping + unboxing | – shipping cost – time from order to treatment delivery – discreet packaging to maintain privacy | 0.5 |
| Test + journal for 1-3 months | – ease of application – transition into habitual use – taste / smell / feel / pain | 1.5 |
| Results after 3 months of use | – efficacy / results – lack of side effects – ease of refill / reordering – quality of ongoing clinical support – responsive customer support – willingness to recommend to a friend | 1.5 |
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