Hair loss affects most American men at some point in their life. While nearly 85% of men experience thinning hair by the time they are 50, one in four starts balding before they turn 21. Hair loss in men, or male pattern baldness, can affect your self-esteem, but the good news is that you don’t have to suffer. Effective medications can slow down or even reverse the development and are readily available through online hair loss treatment.
Two of the best-known treatments are finasteride and dutasteride. Both are powerful medications that work well for many men, but which one is best for you? In this in-depth comparison of finasteride vs dutasteride for hair loss, we’ll review how both drugs work and how they perform in clinical trials. We’ll also take a look at side effects, compare prices, and tell you where to find the prescription for you.
Both medications are proven to treat male pattern hair loss, but there are a few crucial differences between them. Take a look at this comparison, but consider your medical history, potential side effects, and hair loss situation, and make sure you consult with a doctor before making a final decision.
Related reading: Best Finasteride Alternatives for Male Hair Loss
Tl;dr - the bottom line on Finasteride vs Dutasteride
Dutasteride
Scientifically proven effective
- Inhibits the activity of both type 1 and 2 of the 5-alpha-reductase enzymes
- Stronger and more potent than finasteride
- Off-label prescription means that dosages can be more easily customized
- Stays in your body longer, contributing to increased effectiveness but also increased risk of side effects
How do Finasteride and Dutasteride work to prevent hair loss?
To understand how finasteride and dutasteride prevent hair loss, we need to look at what causes the problem in the first place. Most men lose their hair for genetic reasons from a condition known as androgenic alopecia or male-pattern baldness (MPB). Those with the condition have hair follicles that are sensitive to a substance called dihydrotestosterone (DHT).
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DHT is a by-product of testosterone. Testosterone converts to DHT with the help of an enzyme stored in the hair follicle’s oil glands. The enzyme is known as 5-alpha reductase. Once hair follicles sense the presence of DHT, they shrink and shorten the lifespan of each hair. Eventually, the follicles will stop producing hair altogether.
Despite their differences, dutasteride and finasteride have similar modes of action. Both inhibit 5-alpha reductase and therefore prevent the conversion of testosterone into DHT. But there are plenty of differences between the two medications as well.
A brief history of Finasteride & Dutasteride for hair loss
Finasteride
Finasteride was developed in the 1970s and licensed by FDA in the 1990s, first as Proscar, a treatment for benign prostatic hyperplasia (BPH, or enlarged prostate gland), and later as a treatment for male hair loss under the brand name Propecia.
Since then, a generic version of finasteride with the same efficacy has been sold on telemedicine platforms in various forms, such as tablets, solutions, sprays, and so on, and is commonly combined with additional active ingredients such as minoxidil.
Related: Manual Hair Loss Review
Dutasteride
Dutasteride was patented in 1996 and received FDA approval in 2001 as Avodart, a benign prostatic hyperplasia (BPH) treatment. Since it has not yet been approved by the FDA specifically for hair loss, it can only be prescribed “off-label” in the US, but this does not mean it’s ineffective in preventing male pattern baldness – quite the contrary.
Similar to finasteride, dutasteride is also offered by several telemedicine brands in various forms and compounded with other active ingredients to address hair loss from multiple angles. Being sold “off-label” also means that its concentration can be customized, just for you, to the severity of the hair loss.
Is Dutasteride more effective than Finasteride?
Both medications are effective in treating male-pattern baldness, but studies have shown that dutasteride can be more effective than finasteride. But how?
Inhibiting 5-alpha reductase: Despite their differences, both medications act in the same way to prevent testosterone from being converted into DHT by inhibiting 5-alpha reductase (5AR). This enzyme comes in two types known as isoenzymes: type 1 and type 2. Finasteride inhibits type 2, whereas dutasteride inhibits both type 1 and type 2 of the enzyme, preventing more testosterone from being converted.
Half-life (how long it stays in your body): Finasteride and dutasteride differ significantly in their half-life. Dutasteride has a longer half-life (~5 weeks), meaning a single dose can remain in a man’s body for over a month. By comparison, finasteride only has a half-life of approximately five to six hours – it simply has less time than dutasteride to deliver the results you want.
However, the coin is flipped when we start looking at topical applications. Finasteride molecules are smaller than dutasteride molecules, allowing them to penetrate deeper and more efficiently into the scalp.
What the science says: Studies on Finasteride vs Dutasteride effectiveness
Several clinical studies have not only shown the effectiveness of both finasteride and dutasteride. They have also compared the two medications head-to-head (get it?).
According to current research, treating hair loss with dutasteride reduces DHT levels significantly more than with finasteride. Scientists showed dutasteride is 3x more effective than finasteride in inhibiting type 2 5AR. More impressively, perhaps, is that dutasteride is more than 100x more effective at inhibiting type 1 5AR. Looking at oral dutasteride specifically, researchers found that it reduced serum DHT concentrations by up to 90%, whereas finasteride reduced DHT concentrations by 70%.
Those numbers may be impressive, but let’s be real – you’re going to judge the effectiveness of your treatment by looking in the mirror. Analyzing new hair growth confirmed the results measured above. In a comparison study, the dutasteride participants showed significantly more new hair growth after 24 weeks than their counterparts who had taken finasteride.
In addition, the group taking dutasteride also managed to lower their thin hair count, suggesting the medication reversed the miniaturization of hair follicles.
Dutasteride vs Finasteride side effects: Which is safer?
Understanding the effectiveness of a medication tells only part of the story. It’s equally important to consider side effects before choosing one of the options.
Here are some of the common side effects of both finasteride and dutasteride:
- Sexual side effects, including a decreased libido and difficulty achieving or maintaining an erection
- Overall reduction in semen volume and problems with ejaculation
- Breast tenderness and enlargement
- Mental health challenges such as depression
- Allergic reactions
Because both finasteride and dutasteride work by inhibiting the 5AR enzyme and reducing the amount of DHT in the body, they have similar side effects.
However, one main difference between the two is that dutasteride remains in the body for much longer. That means if you are experiencing side effects from the drug, they will take longer to resolve. It can take four to six months for dutasteride to completely leave your system, whereas finasteride only takes several weeks.
Are there other options? Definitely. Both finasteride and dutasteride are available as topical formulations, which are linked to fewer side effects because less of the drug enters the bloodstream than oral medication. Topical medication like Keeps Topical Finasteride reaches the hair follicles directly without first going through the digestive system and liver.
Other topical formulations have been developed specifically to work with your hair follicles. XYON with SiloxysSystem gel uses a unique carrier that delivers finasteride directly to the scalp layer where hair follicles are located, while the gel helps keep most of the active molecules there. Plus, the drug has been formulated to deposit medication gradually over time rather than all at once.
Finasteride vs Dutasteride: What’s the right dose for hair loss?
Both oral medications are typically taken once daily. The most common dose of finasteride is 1mg, whereas dutasteride is usually prescribed in doses of 0.5mg. Dutasteride may have a lower dose than finasteride, but remember that it’s more potent in reducing your DHT levels.
For both, dosages can be adjusted based on the individual client’s response and tolerance to the medication. Adjusting dosages is especially easy when you are using the topical versions. Because dutasteride for hair loss is prescribed ‘off-label,’ it’s even easier to customize your hair loss medication dosages.
What’s more affordable, Finasteride or Dutasteride?
Finasteride tends to be less expensive than dutasteride because it’s FDA-approved and widely available as a low-cost generic drug. Various telemedicine platforms offer convenient subscriptions that deliver monthly or quarterly.
Dutasteride needs to be supplied off-label, which raises the cost. However, this medication can be customized to you, offering additional benefits. Here’s an overview:
Prices of Finasteride & Dutasteride | ||||||
|---|---|---|---|---|---|---|
| Topical finasteride price | $79-119/mo | $59/mo | $99/mo | $45/mo | $60/mo | $50/month (billed $150 quarterly) |
| Oral finasteride price | $24/mo | $17-25/mo | $35/mo | $26/mo | $25/mo | $20/mo |
| Topical dutasteride price | $89/mo | $69/mo | $129/mo | ❌ | ❌ | ❌ |
| Oral dutasteride price | $59/mo | $39/mo | ❌ | ❌ | ❌ | ❌ |
| Other products containing either finasteride or dutasteride? | Topical fin + topical dutasteride + topical min: $119/mo Dutasteride SuperCapsule: $79/mo Finasteride SuperCapsule: $59/mo | Topical fin + supplement: $79/mo Oral fin + supplement: $45/mo Topical dutasteride + oral dutasteride + supplement: $89/mo | ❌ | Oral fin + topical min: ~$41/mo Power pack (oral fin + topical min + thickening shampoo + biotin gummies): $65/mo | Oral fin + topical min: $42/mo | Oral fin + topical min: $35/mo |
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Dutasteride hair loss reviews – Where to get a prescription online?
Online Dutasteride brands | |||
|---|---|---|---|
| Dutasteride options | Topical dropper Oral tablets Oral SuperCapsules | Topical dropper Oral tablets | Topical gel |
| Topical dutasteride formulas & concentrations | 0.3% Dutasteride + Minoxidil ($89/mo) 0.1% Dutasteride + Finasteride + Minoxidil ($119/mo) | 0.1% Dutasteride + Minoxidil + Tretinoin + Fluocinolone ($69/mo) | ≤ 2% Dutasteride + SiloxysSystem Gel ($129/mo) |
| Oral dutasteride formulas & concentrations | Tablet: 0.5mg Dutasteride ($59/mo) SuperCapsule: 0.5mg Dutasteride + Minoxidil + Vitamin D3 ($79/mo) | 0.1-0.6mg Dutasteride with or without Biotin ($39/mo) | ❌ |
| Product bundle options? | ❌ | Topical dutasteride + hair supplement: $89/mo Oral dutasteride + hair supplement: $59/mo | ❌ |
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Finasteride hair loss reviews
Take a look here for online prescriptions of finasteride hair loss products:
Online Finasteride brands | ||||||
|---|---|---|---|---|---|---|
| Finasteride options | Topical spray Oral tablets | Topical gel Oral tablets | Topical spray Oral tablets | Topical dropper Oral tablets Oral Super Capsules | Topical dropper Oral tablets | Topical gel Oral tablets |
| Topical finasteride formulas & concentrations | 0.3% Finasteride + Minoxidil ($45/mo) | 0.25% Finasteride + Minoxidil ($60/mo) | 0.3% Finasteride + Minoxidil + Tretinoin ($50/mo) | 0.3% Finasteride + Minoxidil ($79/mo) .25% Finasteride + Minoxidil Aqueous Formula ($119/mo) 0.1% Finasteride + Dutasteride + Minoxidil ($119/mo) | 0.1-0.25% Finasteride + Minoxidil + Tretinoin + Fluocinolone ($59/mo) | ≤ 2.5% Finasteride + SiloxysSystem Gel ($99/mo) |
| Oral finasteride formulas & concentrations | 1mg Finasteride ($26/mo) | 1mg Finasteride ($25/mo) | 1mg Finasteride ($20/mo) | Tablet: 1mg Finasteride ($24/mo) SuperCapsule: 1mg Finasteride + Minoxidil + Vitamin D3 ($59/mo) | 1mg Finasteride ($25/mo) | 1mg Finasteride ($35/mo) |
| Product bundle options? | Oral fin + topical min: ~$41/mo Power pack (oral fin + topical min + thickening shampoo + biotin gummies): $65/mo | Oral fin + topical min: $42/mo | Oral fin + topical min: $35/mo | ❌ | Topical fin + hair supplement: $79/mo Oral fin + hair supplement: $45/mo | ❌ |
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The Verdict: Should you try Dutasteride or Finasteride for Alopecia?
Put simply, there is no right or wrong choice here, it all depends on what you’re looking for in your hair regrowth journey.
Finasteride is ideal for guys who… | |
…are in the beginning stages of hair loss.Because Finasteride is proven more efficient at slowing or stopping hair loss than regrowing hair, oral or topical finasteride could be a great choice if you’re just showing the first signs of hair loss. It’s also a more cost-effective alternative because it’s a generic medication, so it makes the most sense as a first step.
Finasteride is FDA-approved for hair loss and has a lower potential for side effects due to its shorter half-life (time spent in the body). This can mean lower efficacy over time but could be worth it if you want to avoid adverse sexual reactions. Another way to avoid this is by choosing the topical formulation over oral finasteride. Numerous brands offer combo packages of topical finasteride + minoxidil, allowing you to combine two approaches to treating hair loss.
Happy Head offers the most variations of finasteride for hair loss, available as a topical dropper formula and two different oral options.
| |
Dutasteride is ideal if you… | |
…want to spend the extra $$ on a custom, potent prescription.Dutasteride attacks hair loss concerns with the most effective medication on the market, delivering outstanding hair growth and stopping hair thinning by inhibiting both types of the enzyme responsible for male pattern baldness. If you’re willing to spend the extra money on an off-label prescription (not FDA-approved for hair loss), you’ll also have the option for greater customization of medication dosage.
The longer half-life of dutasteride can mean more potential for side effects, but it also means the medication has more time to work, therefore offering more efficacy in treating male pattern baldness. Finasteride blocks about 70% of DHT, while dutasteride can block more than 90%.
XYON provides topical dutasteride combined with its revolutionary SiloxysSystem gel formula for greater penetration. Strut offers the most options for dutasteride with both oral and topical formulas, and also offers bundles at a lower price to include hair supplements for increased hair growth.
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Frequently Asked Questions (FAQs)
How can I get dutasteride for hair loss?
Telemedicine platforms like Happy Head, Strut, and XYON all offer dutasteride in different forms. Which product to choose depends on whether you are looking for the strongest possible dose – pills and capsules may work better – or would like to avoid potential side effects by applying your medication topically. Most brands also offer combination packages, allowing you to tackle hair loss from multiple angles.
Happy Head offers the most combinations of dutasteride, Strut provides bundles with other products, while XYON combines its topical formula with patented SiloxysSystem Gel, all at different prices (check our dutasteride pricing chart).
Can you combine dutasteride and finasteride?
It’s possible to combine dutasteride and finasteride in topical products. Happy Head is one of the brands offering that combination, even adding minoxidil to its formulation. When it comes to pills, combining both ingredients is not recommended. However, adding minoxidil to either finasteride or dutasteride works well.
Are finasteride and dutasteride FDA-approved for hair loss?
Finasteride has been FDA-approved for hair loss. Dutasteride is currently only FDA-approved as a medication for benign prostate gland enlargement. Nevertheless, studies have proven the effectiveness of dutasteride for hair loss, and prescriptions are available ‘off-label’ to treat hair loss.
Curious where to start?
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